Co-enzyme Q-10 in Animals

Co-enzyme Q-10 increases mitochondrial energy production in cells possibly through down-regulating the level of nitric oxide.  It has been touted for use in patient’s with cardiac disease to improve cell function.  I have had a few clients try this in dogs and cats with heart disease.  Unfortunately, I did not see any improvement in these patients.  Recently I came across a study that demonstrated CoQ10 might help diabetic patients with heart disease based on research in mice but the investigators recommended further investigation.   

Beside heart disease, Co-enzyme Q-10 has been reported to improve gingivitis in humans although I haven’t had any experience with this.  I know that some veterinarians are recommending this nutraceutical for canine cognitive dysfunction although there are no scientific studies yet to back up this use.  I did find one study that showed Co-enzyme Q-10 protected against cognitive impairments and hippocampal neuronal degeneration caused by organophosphates.  

-Binukumar, B.K., et. al., “Protective efficacy of co-enzyme Q-10 against DDVP-induced cognitive impairments and neurodegeneration in rats.” Neutox Res. May 2012;21(4): 345-57.
-Huymh,K. et. al., “Coenzyme Q10 attenuates diastolic dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis in the db/db mouse model of type 2 diabetes” Diabetologica May 2012;55(5):1544-53.
-Jung, Hynn-Joo, et. al., “Evaluation of anti-angiogenic, anti-inflammatory and antinociceptive activity of coenzyme Q(10) in experimental animals.” J. Pharm Pharmocol. October 2009;61(10):1391-5.
-Warren, E. ‘Nutraceuticals’ The VSPN notebook, 4/4/2007.

Published by kristennelsondvm

Dr. Kristen Nelson grew up on a farm in Watertown, Minn., where she developed a deep love for animals of all kinds. She received a Doctor of Veterinary Medicine degree from the University of Minnesota, College of Veterinary Medicine. Kris then completed a small-animal internship at the prestigious Animal Medical Center in New York City. In addition to writing and speaking, she cares for small and exotic animals in Scottsdale, Az. Dr. Nelson is widely quoted in the media. Her credits include Ladies’ Home Journal, USA TODAY, the Los Angeles Times and numerous radio and television interviews. Dr. Nelson has written two books, Coated With Fur: A Vet’s Life and Coated With Fur: A Blind Cat’s Love. Kris and her husband Steve share their home with rescued cats, birds and a dog.